病態解析・診断学の紹介

長崎大学病院検査部
〒852-8501
長崎市坂本１丁目７番１号
Department of LABORATORY MEDICINE
HOME＞病態解析・診断学の紹介＞研究活動＞研究業績＞２０１０年
研究活動：研究業績（２０１０年）

A　欧文

  1. Morinaga Y, Yanagihara K, Nakamura S, Hasegawa H, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Yamada Y, Kohno S, Kamihira S:  Legionella pneumophila Induces Cathepsin B-dependent Necrotic Cell Death with Releasing High Mobility Group Box1 in Macrophages.  Respiratory Research 11:158, 2010(IF:3.127)
  2. Araki N, Yanagihara K, Morinaga Y, Yamada K, Nakamura S, Yamada Y, Kohno S, Kamihira:  Azithromycin inhibits nontypeable Haemophilus influenzae-induced MUC5AC expression and secretion via inhibition of activator protein -1 in human airway epithelial cells.  European Journal of Pharmacology 644(1-3):209-14, 2010(IF:2.585)
  3. Sasaki D, Doi Y, Hasegawa H, Yanagihara K, Tsukasaki K, Iwanaga M, Yamada Y, Watanabe T, Kamihira S:  High Human T Cell Leukemia Virus Type-1(HTLV-1) Provirus Load in Patients with HTLV-1 Carriers Complicated with HTLV-1-unrelated disorders. Virol J 7(1):81, 2010(IF:2.435)
  4. Yanagihara　K, Kitagawa Y, Tomonaga M, Tsukasaki K, Kohno S, Seki M, Sugimoto H, Shimazu T, Tasaki O, Matsushima A, Ikeda Y, Okamoto S, Aikawa N, Hori S, Obara H, Ishizaka A, Hasegawa N, Takeda J, Kamihira S, Sugahara K, Asari S, Murata M, Kobayashi Y, Ginba H, Sumiyama Y, Kitajima M:  Evaluation of Pathogen Detection from Clinical Samples by Real-Time PCR using a Sepsis Pathogen DNA Detection Kit.  Critical Care 14(4):R159, 2010(IF:4.931)
  5. Morinaga Y, Yanagihara K, Araki N, Yamada K, Nakamura S, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, H. Mukae, Yamada Y, Kohno S, Kamihira S:  In Vivo Efficacy of Sivelestat in Combination with Pazufloxacin against Legionella Pneumonia.  Experimental Lung Research 36(8):484-90, 2010(IF:1.177)
  6. Miyazaki T, Inamine T, Yamauchi S, Nagayoshi Y, Saijo T, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S:  Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata.  FEMS Yeast Res 10(3):343-52, 2010(IF:1.785)
  7. Lynch SV, Flanagan JL, Sawa T, Fang A, Baek MS, Rubio-Mills A, Ajayi T, Yanagihara K, Hirakata Y, Kohno S, Misset B, Nguyen JC, Wiener-Kronish JP:  Polymorphisms in the Pseudomonas aeruginosa Type III secretion protein,PcrV - implications for anti-PcrV Immunotherapy.  Microb Pathog 48(6):197-204, 2010(IF:2.324)
  8. Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y:  Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan. 　J Med Virol 82(4):668-674, 2010(IF:2.470)
  9. Miyazaki T, Yamauchi S, Inamine T, Nagayoshi Y, Saijo T, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S:  Roles of Calcineurin and Crz1 in Antifungal Susceptibility and Virulence of Candida glabrata. Antimicrob Agents Chemother 54(4):1639-43, 2010(IF:4.802)
  10. Motoshima M, Yanagihara K, Morinaga Y, Matsuda J, Sugahara K, Yamada Y, Kohno S, Kamihira:  S Genetic Diagnosis of Community-Acquired MRSA: A Multiplex Real-Time PCR Method for Staphylococcal Cassette Chromosome mec Typing and Detecting Toxin Genes.  Tohoku J Exp Med 220(2):165-70, 2010(IF:1.347)
  11. Saijo T, Miyazaki T, Izumikawa K, Mihara T, Takazono T, Kosai K, Imamura Y, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S:  Skn7p Is Involved in Oxidative Stress Response and Virulence of Candida glabrata. Mycopathologia 169(2):81-90, 2010(IF:1.728)
  12. Mukae H, Urabe K, Yanagihara K, Ishimoto H, Sakamoto N, Ishii H, Nakayama S, Ishimatsu Y, Abe K, Shirai R and Kohno S:  Low Expression of T-cell Co-stimulatory Molecules in Bone Marrow-Derived Dendritic Cells in a Mouse Model of Chronic Respiratory Infection with Pseudomonas aeruginosa.  Tohoku J Exp Med 220(1):59-65, 2010(IF:1.347)
  13. Nakamura S, Yanagihara K, Araki N, Yamada K, Morinaga Y, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Kamihira S, Kohno S:  Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice.  Antimicrob Agents Chemother 54(2):757-62, 2010(IF:4.802)
  14. Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y:  CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells.  J Biol Chem 285(20):15511-22, 2010. Epub 2010 Mar 9 (IF:5.328)
  15. Horie I, Ando T, Inokuchi N, Mihara Y, Miura S, Imaizumi M, Usa T, Kinoshita N, Sekine I, Kamihara S, Eguchi K:   First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma.  Endocr J 57(4):287-92, 2010. Epub 2010 Jan 6 (IF:1.806)
  16. Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, Maeda T:  Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women.  Biomarkers 15(4):340-4, 2010 (IF:1.608)
  17. Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T, Yamada Y, Kamihira S, Ikeda S, Miyazaki Y, Tomonaga M, Tsukasaki K:  Long-term study of indolent adult T-cell leukemia-lymphoma.  Blood 115(22):4337-43, 2010.  Epub 2010 Mar 26 (IF:10.555)
  18. Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T:  Intra- and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays: a multi-center study.  Cancer Sci 101(11):2361-7, 2010 (IF:3.771)
  19. Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K:  Joint Study on Predisposing Factors of ATL Development investigators.  Blood 116(8):1211-9, 2010. Epub 2010 May 6 (IF:10.555)
  20. Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T:  Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis.  Blood 117(2):500-9, 2010. Epub 2010 Oct 18 (IF:10.555)
  21. Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R: Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. J Clin Oncol 28:1591-1598, 2010 (IF:17.793)

A-b

  1. Kaku N, Seki M, Doi S, Hayashi T, Imanishi D, Imamura Y, Kurihara S, Miyazaki T,Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Tashiro T, Kohno S:  A case of intravascular large B-cell lymphoma (IVLBCL) with no abnormal findings on chest computed tomography diagnosed by random transbronchial lung biopsy.  Intern Med 49(24):2697-701, 2010(IF:1.040)
  2. Yamamoto Y, Izumikawa K, Hara A, Fujita H, Amenomori M, Sakamoto N, Seki M, Kakeya H, Yanagihara K, Takasaki K, Miyazaki T, Tsuchiya T, Yamasaki N, Tagawa T, Nagayasu T, Kohno S:  Importance of Controlling Drug-resistant Pseudomonas aeruginosa Infection: Experience from Lung Transplantation in a Cystic Fibrosis Case.  Intern Med 49(21):2353-8, 2010(IF:1.040)
  3. Izumikawa K, Nakano K, Kurihara S, Imamura Y, Yamamoto K, Miyazaki T, Sakamoto N, Seki M, Ishimatsu Y, Kakeya H, Yamamoto Y, Yanagihara K, Tsuchiya T, Yamasaki N, Tagawa T, Mukae H, Nagayasu T, Kohno S:  Diffuse Alveolar Hemorrhage following Itraconazole Injection. 　Intern Med 49(5):497-500, 2010(IF:1.040)
  4. Morinaga Y, Yanagihara K, Masunaga K, Hashiguchi M, Okamura T, Watanabe H, Kohno S, Kamihira S:  Invasive pneumococcal disease in a traveler who returned from Philippine: a case report and in vivo study of the isolate.  Journal of Travel Medicine 17(1):63-5, 2010(IF:1.503)

B　邦文


B-a
  1. 赤松紀彦、栁原克紀、松田淳一、木谷貴嘉、菅原和行、山田舞子、森　沙耶香、山田恭暉、上平　憲：コバスアンプリコアのPCR増幅産物をテンプレートとしたSecond Step PCR法によるMycobacterium kansasiiの検出法．日本臨床微生物学会誌　20(2):21－25，2010
  2. 尾坂明美、長谷川寛雄、山田恭暉、栁原克紀典、長井一浩、宮西隆幸、小路武彦、菱川義隆、上平　憲：細胞死における酸化ストレスのもたらすHMGB1分子の変化．日本臨床化学会九州支部会誌　25-26, 2010
  3. 土井裕子、臼井哲也、佐々木大介、森沙耶香、寺田千春、鶴田一人、山田恭暉、上平　憲：Chimeric ABL変異イマチニブ耐性CMLにダサチニブ投与後、新たな変異を認めた一例．日本臨床化学会九州支部会誌　36-37, 2010
  4. 寺田千春、鶴田一人、佐々木大介、森沙耶香、土井裕子、山田恭暉、上平　憲：骨髄増殖性腫瘍(MPN)におけるJAK2 mutation解析．日本臨床化学会九州支部会誌　39-40, 2010
  5. 土屋健史、岩永正子、境　麻里、塚崎邦弘、上平　憲、三根真理子、横田賢一、朝長万左男、松尾辰樹、宮崎泰司：長崎県原爆被爆者における多発性骨髄腫検診(第7報)－MGUSの予後調査－．長崎医学会雑誌　85:272-277, 2010
  6. 森永芳智、栁原克紀、山田康一、中村茂樹、泉川公一、関　雅文、掛屋　弘、山本善裕、井上祐一、上平　憲、河野　茂：Corynebacterium pseudodiphtheriticum による呼吸器感染症の2例．感染症学雑誌　84(1):65-68, 2010
  7. 池ノ下友里、臼井哲也、南　惣一郎、山田恭暉、上平　憲：血糖自己測定(SMBG)各機種の環境温度による影響について、医療と検査機器・試薬　33(3):383-385, 2010
  8. 古賀嘉人、猪口直子、佐々木大介、植木麻友、園山里美、香川孝司、上平　憲：化学発光酵素免疫測定法を測定原理とした新規抗HTLV-1抗体検出試薬の評価、医学検査　59(5):727-731, 2010

B-b

  1. 栁原克紀、上平　憲：呼吸器感染症診療における迅速検査の現状と将来．臨床病理　58(5):508-516，2010
  2. 山田康一、栁原克紀：第4章　知っておきたい耐性菌の現状　1．耐性菌の現状．月刊薬事　52(9):107-111, 2010
  3. 山田康一、栁原克紀：感染症に強くなる　3．話題の耐性菌．月刊レジデント　3(7):25-31, 2010
  4. 荒木伸子、栁原克紀：感染症における「薬が効かない」現象．医薬ジャーナル社　46(5):111-115, 2010
  5. 栁原克紀：病院・医療施設における感染対策　インフルエンザ．最新医学　65(1):91－95, 2010
  6. 栁原克紀　河野　茂：呼吸器疾患の新治療　クラビット500．呼吸　29(2):157－162, 2010
  7. 鶴田一人、濱﨑典子、松野貴子、森内拓治、跡上　直、上平　憲：広範囲 血液・尿化学検査　免疫学検査　－その数値をどう読むか－［第７版］（３）、IX.免疫学的検査　I.細胞性免疫　CD抗体によるｸﾞﾙｰﾌﾟ分類　T細胞CD抗原、B細胞系CD抗原、骨髄細胞系CD抗原－造血機腫瘍細胞を中心に－．日本臨床　68(6):847-854, 2010
  8. 森永芳智、栁原克紀、上平　憲：広範囲 血液・尿化学検査　免疫学検査　－その数値をどう読むか－［第７版］（３）、IX.免疫学的検査　E.感染症関連検査(抗原および抗体を含む)　非ウィルス性感染症　マイコプラズマ・ニューモニエ．日本臨床　68(6):234-236, 2010
  9. 長谷川寛雄、山田恭暉、上平　憲：特集　腫瘍細胞のMDM2特異的阻害剤Nutlin-3aに対する感受性とp53変異．臨床化学　39(3):246-252, 2010

B-c

  1. 山田恭暉：成人T細胞白血病・リンパ腫（横田千津子、池田宇一、大越教夫（編集）：病気と薬パーフェクトBOOK 2010、南山堂、東京、PP.1665-1671所収）2010
  2. 上平　憲：抗ﾋﾄT細胞白血病ウィルスタイプ－１(ATLV)抗体 [ ﾋﾄT細胞白血病ｳｨﾙｽI型（HTLV-1）抗体 ] anti-HTLV-1 antibodies．(中原一彦（監修）：パーフェクトガイド　検査値事典　V．感染症検査、　総合医学社、東京、P556所収) 2010
  3. 上平　憲：ﾋﾄ免疫不全ウィルス(HIV)抗体　anti-HIV antibodies．(中原一彦（監修）：パーフェクトガイド　検査値事典　V．感染症検査、　総合医学社、東京、P557所収) 2010